产碳青霉烯酶所致自发性细菌性腹膜炎：病因与抗生素治疗
Spontaneous bacterial peritonitis due to carbapenemase-producing : Etiology and antibiotic treatment.
作者信息
Fiore Marco, Di Franco Sveva, Alfieri Aniello, Passavanti Maria Beatrice, Pace Maria Caterina, Petrou Stephen, Martora Francesca, Leone Sebastiano
机构信息
Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy.
Department of Emergency Medicine, Good Samaritan Hospital Medical Center, NY 11795, United States.
出版信息
World J Hepatol. 2020 Dec 27;12(12):1136-1147. doi: 10.4254/wjh.v12.i12.1136.
Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria. Over the last decade, carbapenem-resistant (CRE) have emerged as organisms causing spontaneous bacterial peritonitis. Infections caused by CRE have shown a higher mortality rate than those caused by bacteria sensitive to carbapenem antibiotics. Current antibiotic guidelines for the treatment of spontaneous bacterial peritonitis are insufficient, and rapid de-escalation of empiric antibiotic treatment is not widely recognized. This review summarizes the molecular characteristics, epidemiology and possible treatment of spontaneous bacterial peritonitis caused by CRE.
碳青霉烯类抗生素于20世纪80年代首次被引入，长期以来一直被认为是治疗多重耐药革兰氏阴性菌的最有效药物。在过去十年中，耐碳青霉烯类肠杆菌科细菌（CRE）已成为引起自发性细菌性腹膜炎的病原体。CRE引起的感染死亡率高于对碳青霉烯类抗生素敏感的细菌引起的感染。目前治疗自发性细菌性腹膜炎的抗生素指南并不充分，经验性抗生素治疗的快速降阶梯尚未得到广泛认可。本综述总结了CRE引起的自发性细菌性腹膜炎的分子特征、流行病学及可能的治疗方法。
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