Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Department of Nutrition & Food Sciences, Nutrition & Microbiota, University of Bonn, Bonn, Germany.
Biomark Med. 2021 Feb;15(2):137-148. doi: 10.2217/bmm-2020-0353. Epub 2021 Jan 14.
The association of gut microbiota dysbiosis with various human diseases is being substantiated with increasing evidence. Metabolites derived from both, microbiota and the human host play a central role in disease susceptibility and disease progression by extensively modulating host physiology and metabolism. Several of these metabolites have the potential to serve as diagnostic biomarkers for monitoring disease states in conjunction with intestinal microbiota dysbiosis. In this narrative review we evaluate the potential of trimethylamine-N-oxide, short-chain fatty acids, 3-indoxyl sulfate, -cresyl sulfate, secondary bile acids, hippurate, human β-defensin-2, chromogranin A, secreted immunoglobulins and zonulin to serve as biomarkers for metabolite profiling and diagnostic suitability for dysbiosis and disease.
越来越多的证据证实，肠道微生物群落失调与各种人类疾病有关。微生物群和人类宿主衍生的代谢物通过广泛调节宿主生理和代谢，在疾病易感性和疾病进展中发挥核心作用。其中一些代谢物有可能作为诊断生物标志物，与肠道微生物群落失调一起监测疾病状态。在这篇叙述性综述中，我们评估了氧化三甲胺、短链脂肪酸、3-吲哚硫酸、-对甲酚硫酸、次级胆酸、马尿酸、人β-防御素-2、嗜铬粒蛋白 A、分泌型免疫球蛋白和紧密连接蛋白作为代谢物分析和诊断微生物群落失调和疾病的生物标志物的潜力。
