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温度依赖性的fasciation 突变体为线粒体 RNA 加工和侧根形态发生之间提供了联系。

Temperature-dependent fasciation mutants provide a link between mitochondrial RNA processing and lateral root morphogenesis.

机构信息

Botanical Gardens, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Department of Molecular and Functional Genomics, Interdisciplinary Center for Science Research, Shimane University, Shimane, Japan.

出版信息

Elife. 2021 Jan 14;10:e61611. doi: 10.7554/eLife.61611.

DOI:10.7554/eLife.61611
PMID:33443014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7846275/
Abstract

Although mechanisms that activate organogenesis in plants are well established, much less is known about the subsequent fine-tuning of cell proliferation, which is crucial for creating properly structured and sized organs. Here we show, through analysis of temperature-dependent fasciation (TDF) mutants of Arabidopsis, (), , and (), that mitochondrial RNA processing is required for limiting cell division during early lateral root (LR) organogenesis. These mutants formed abnormally broadened (i.e. fasciated) LRs under high-temperature conditions due to extra cell division. All TDF proteins localized to mitochondria, where they were found to participate in RNA processing: RRD1 in mRNA deadenylation, and RRD2 and RID4 in mRNA editing. Further analysis suggested that LR fasciation in the TDF mutants is triggered by reactive oxygen species generation caused by defective mitochondrial respiration. Our findings provide novel clues for the physiological significance of mitochondrial activities in plant organogenesis.

摘要

虽然植物器官发生的机制已经得到很好的确立，但对于细胞增殖的后续精细调控知之甚少，而细胞增殖对于创建结构和大小适当的器官至关重要。在这里，我们通过对拟南芥温度依赖性分形（TDF）突变体（）、（）、和（）的分析表明，线粒体 RNA 加工对于限制早期侧根（LR）器官发生过程中的细胞分裂是必需的。这些突变体由于额外的细胞分裂，在高温条件下形成异常增宽的（即分形的）LR。所有的 TDF 蛋白都定位于线粒体，在那里它们被发现参与 RNA 加工：RRD1 参与 mRNA 去腺苷酸化，RRD2 和 RID4 参与 mRNA 编辑。进一步的分析表明，TDF 突变体中的 LR 分形是由线粒体呼吸缺陷引起的活性氧产生触发的。我们的发现为线粒体活动在植物器官发生中的生理意义提供了新的线索。

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