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[地布诺尔抗诱变作用的机制]

[Mechanism of the antimutagenic action of dibunol].

作者信息

Bakhitova L M, Kolonina I V

出版信息

Radiobiologiia. 1988 Jan-Feb;28(1):111-3.

PMID:3344319
Abstract

In experiments with cultured V-79 Chinese hamster cells a study was made of the influence of dibunol on the level of gamma-radiation-induced micronuclei and sedimentation properties of cell nucleoids during ultracentrifugation in a neutral sucrose gradient. Protection of DNA molecule against the effects of both primary and secondary damages was found to be involved in the mechanism of the protective action of dibunol.

摘要

在用培养的V - 79中国仓鼠细胞进行的实验中,研究了二丁醇对γ射线诱导的微核水平以及细胞类核在中性蔗糖梯度超速离心过程中的沉降特性的影响。发现二丁醇的保护作用机制涉及保护DNA分子免受一级和二级损伤的影响。

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