[GGS-10气态低氧混合物对大鼠正常组织和肉瘤45的DNA超分子复合物的辐射防护作用]
[Radioprotective action of a GGS-10 gaseous hypoxic mixture on the DNA supramolecular complex of normal tissues and sarcoma 45 of rats].
作者信息
Strazhevskaia N B, Struchkov V A
出版信息
Radiobiologiia. 1988 Jan-Feb;28(1):114-6.
PMID:3344320
Abstract
Gas hypoxic mixture (GHM-10) inhaled by rats during gamma-irradiation (2 to 20 Gy) effectively protects the supramolecular complex of DNA (SC DNA) in bone marrow and spleen, but fails to protect this complex in sarcoma 45. GHM-10 itself has been shown to induce rapid and prolonged, but irreversible, decrease in SC DNA elastic viscosity in normal tissues.
摘要
在γ射线照射（2至20戈瑞）期间，大鼠吸入的气体低氧混合物（GHM - 10）能有效保护骨髓和脾脏中DNA的超分子复合物（SC DNA），但无法保护肉瘤45中的该复合物。已证明GHM - 10本身会导致正常组织中SC DNA弹性粘度迅速且持续但不可逆地降低。
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