组织特异性肾上腺素调节 L 型钙通道 Ca1.2。
Tissue-specific adrenergic regulation of the L-type Ca channel Ca1.2.
机构信息
Department of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
出版信息
Sci Signal. 2020 Dec 22;13(663):eabc6438. doi: 10.1126/scisignal.abc6438.
Abstract
Ca influx through the L-type Ca channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca influx through Ca1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Ca1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.
摘要
钙离子通过 L 型钙通道 Cav1.2 流入引发每次心跳。战斗或逃跑反应会诱导应激反应激素去甲肾上腺素的释放，以刺激β肾上腺素能受体、cAMP 的产生和蛋白激酶 A 的活性，从而增强钙离子通过 Ca1.2 的流入，进而增强心肌细胞的收缩力。新出现的证据表明，与神经元和血管平滑肌细胞相比，心肌细胞中 Ca1.2 的调节机制不同。
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