Ag 催化的叔环烷醇的开环反应用于环状亚胺的 C-H 官能化。
Ag-Catalyzed ring-opening of tertiary cycloalkanols for C-H functionalization of cyclic aldimines.
机构信息
Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, China.
College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China.
出版信息
Chem Commun (Camb). 2021 Feb 15;57(12):1506-1509. doi: 10.1039/d0cc07181a.
We firstly describe a silver-catalyzed direct C-H functionalization of cyclic aldimines with cyclopropanols and cyclobutanols via a radical-mediated C-C bond cleavage strategy. The desired products were generated in decent yields with wide substrate scope under mild reaction conditions. In addition, a gram-scale reaction and synthetic transformation of the product were performed.
我们首先描述了一种通过自由基介导的 C-C 键断裂策略，用环丙醇和环丁醇催化环状亚胺的直接 C-H 官能化反应。在温和的反应条件下，以中等至良好的收率和广泛的底物范围得到了所需产物。此外，还进行了克级反应和产物的合成转化。
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