通过无张力环烷醇的开环反应制备卤代烯丙基酮
Halogen-Substituted Allenyl Ketones through Ring Opening of Nonstrained Cycloalkanols.
作者信息
Wu Penglin, Ma Shengming
机构信息
Research Center for Molecular Recognition and Synthesis, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China.
出版信息
Org Lett. 2021 Apr 2;23(7):2533-2537. doi: 10.1021/acs.orglett.1c00452. Epub 2021 Mar 18.
An efficient synthesis of halogen-substituted allenyl ketones via Ag-catalyzed oxidative ring opening of allenyl cyclic alcohols under mild reaction conditions has been achieved. The reaction features a wide substrate scope and excellent regioselectivity. The synthetic potential of the products has been demonstrated by their conversion to stereodefined alkenes and heterocyclic compounds.
在温和的反应条件下，通过银催化的烯丙基环醇氧化开环反应，实现了卤代烯丙基酮的高效合成。该反应具有广泛的底物范围和优异的区域选择性。通过将产物转化为立体定向烯烃和杂环化合物，证明了这些产物的合成潜力。
Zotero 插件