Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
Org Lett. 2021 Feb 5;23(3):936-942. doi: 10.1021/acs.orglett.0c04138. Epub 2021 Jan 14.
A copper-based catalytic system has been developed to enable efficient cyclization of ketoxime acetates with -fluorobenzaldehydes. This protocol offers an efficient method for the synthesis of substituted quinoline derivatives with a broad range of compatible functionalities. The present system also provides a rapid access to synthetically and pharmaceutically useful quinoline-fused polycycles such as benzo[]acridines.
开发了一种基于铜的催化体系，以实现酮肟乙酸酯与-氟苯甲醛的高效环化反应。该方案为合成具有广泛兼容官能团的取代喹啉衍生物提供了一种有效方法。本体系还为合成和药物有用的喹啉稠合多环化合物（如苯并[ ]吖啶）提供了快速途径。
