From the Department of Nuclear Medicine, Marmara University Istanbul Pendik Training and Research Hospital, Istanbul, Turkey.
Clin Nucl Med. 2021 Jul 1;46(7):e371-e372. doi: 10.1097/RLU.0000000000003482.
Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein, which is overexpressed in prostate cancer cells. With its wide use, there is a growing number of case reports describing non-prostate cancer-related benign and malignant lesions showing increased 68Ga-PSMA uptake. We herein present the case of an 89-year-old man with prostate cancer who was referred for 68Ga-PSMA PET/CT for restaging, which revealed incidental 68Ga-PSMA uptake in compression fracture of a vertebral body. This case demonstrates that PSMA expression may occur in acute compression fractures, and it can be a potential pitfall when reporting 68Ga-PSMA PET/CT images.
前列腺特异性膜抗原（PSMA）是一种膜糖蛋白，在前列腺癌细胞中过度表达。随着其广泛应用，越来越多的病例报告描述了非前列腺癌相关的良性和恶性病变显示出增加的 68Ga-PSMA 摄取。本文介绍了一例 89 岁前列腺癌男性患者，因进行 68Ga-PSMA PET/CT 分期而被转介，该患者在椎体压缩性骨折中发现了偶然的 68Ga-PSMA 摄取。该病例表明 PSMA 表达可能发生在急性压缩性骨折中，在报告 68Ga-PSMA PET/CT 图像时可能是一个潜在的陷阱。
