Lee Younjung, Kim Kye-Hyun, Lee Bun-Hee, Kim Yong-Ku
Department of Psychiatry, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea.
Department of Obstetrics & Gynecology, KangBuk Samsung Hospital, College of Medicine, Sungkyunkwan University, Seoul, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jul 13;109:110245. doi: 10.1016/j.pnpbp.2021.110245. Epub 2021 Jan 11.
Postpartum depression occurs in 10-15% of mothers. Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays a role in neuroplasticity. We hypothesized that the concentration of BDNF is related to reproduction and childbirth, and that women with postpartum depression show alteration in BDNF level. A total of 104 pregnant women was selected as subjects, and 60 non-pregnant women were selected as normal controls. Symptoms of depression were evaluated in the pregnant study subjects using the diagnostic criteria outlined in the Edinburgh Postnatal Depression Scale (EPDS). The pregnant subjects were divided into three groups of perinatal non-depressed controls (n = 61), postpartum depression-recovery (n = 18), and postpartum depression (n = 25). The plasma concentration of BDNF was higher in the pregnant group than in non-pregnant controls and lower in the postpartum depression group at 6 weeks after delivery than in the perinatal non-depressed group. In the postpartum depression-recovery group, the BDNF concentration increased at 6 weeks after delivery compared to that at 24 weeks of gestation. This study found significant changes in plasma BDNF concentration in depressed pregnant women.
10%至15%的母亲会发生产后抑郁症。脑源性神经营养因子（BDNF）是一种在神经可塑性中起作用的神经生长因子。我们假设BDNF的浓度与生殖和分娩有关，并且产后抑郁症女性的BDNF水平会发生改变。总共选取了104名孕妇作为研究对象，并选取60名非孕妇作为正常对照。使用爱丁堡产后抑郁量表（EPDS）中概述的诊断标准对怀孕的研究对象进行抑郁症状评估。将怀孕的研究对象分为三组：围产期非抑郁对照组（n = 61）、产后抑郁康复组（n = 18）和产后抑郁症组（n = 25）。怀孕组的血浆BDNF浓度高于非怀孕对照组，且产后抑郁症组在产后6周时的血浆BDNF浓度低于围产期非抑郁组。在产后抑郁康复组中，与妊娠24周时相比，产后6周时BDNF浓度升高。本研究发现抑郁孕妇的血浆BDNF浓度有显著变化。
