Biobehavioral Laboratory, School of Nursing, University of North Carolina at Chapel Hill, NC, United States.
Biobehavioral Laboratory, School of Nursing, University of North Carolina at Chapel Hill, NC, United States.
J Affect Disord. 2021 Mar 1;282:617-626. doi: 10.1016/j.jad.2020.12.193. Epub 2020 Dec 31.
Few studies have explored the relationship between psychological, psychosocial and biological factors among Latinas. An integrated understanding of how these factors associate with psychological distress is necessary for the development of culturally relevant screening tools and interventions. The study aim was to examine the relationships among (a) psychological distress symptoms, (b) psychosocial factors (discrimination, acculturation, acculturative stress, economic hardship), and (c) biological (DNA methylation of stress-related genes) factors among Latinas during pregnancy and postpartum period.
A sample of 150 pregnant Latinas completed the Inventory of Depression and Anxiety Symptoms II (IDAS-II), psychosocial questionnaires (discrimination, acculturation, acculturative stress, economic hardship) before (24-32 weeks) and after gestation (4-6 weeks postpartum). Blood samples were collected between 24-32 weeks gestation. Correlations were determined between psychosocial and biological measures and psychological distress measures. Multivariable linear regression models were conducted to assess the relationships between IDAS and stressors.
Several correlations among psychosocial measures,DNA methylation factors and IDAS-II variables were identified. Among the psychosocial measures, everyday discrimination was the most strongly and consistently associated with IDAS-II. DNA methylation of NR3C1 affects the associations between psychological and psychosocial distress.
We only assessed DNA methylation during pregnancy and focused on four HPA-related genes. Longitudinal assessment of DNA methylation and genome-wide analysis can provide a better picture of the role of methylation in psychological distress.
This work may assist clinicians and policy makers in effectively recognizing and preventing maternal mental health disparities based on discrimination and other psychosocial stressors in at-risk groups.
很少有研究探讨拉丁裔人群中心理、心理社会和生物因素之间的关系。为了开发出与文化相关的筛查工具和干预措施，有必要综合了解这些因素与心理困扰之间的关联。本研究旨在探讨妊娠和产后期间拉丁裔女性（a）心理困扰症状，（b）心理社会因素（歧视、文化适应、文化适应压力、经济困难），和（c）生物（应激相关基因的 DNA 甲基化）因素之间的关系。
150 名孕妇拉丁裔完成了抑郁和焦虑症状量表第二版（IDAS-II）、心理社会问卷（歧视、文化适应、文化适应压力、经济困难），在妊娠前（24-32 周）和妊娠后（产后 4-6 周）进行。在妊娠 24-32 周期间采集血样。确定心理社会和生物测量与心理困扰测量之间的相关性。采用多元线性回归模型评估 IDAS 与应激源之间的关系。
确定了心理社会测量、DNA 甲基化因素和 IDAS-II 变量之间的几个相关性。在心理社会测量中，日常歧视与 IDAS-II 的关联最强烈和一致。NR3C1 的 DNA 甲基化影响心理和心理社会困扰之间的关联。
我们仅在妊娠期间评估 DNA 甲基化，并专注于四个 HPA 相关基因。DNA 甲基化的纵向评估和全基因组分析可以更好地了解甲基化在心理困扰中的作用。
这项工作可以帮助临床医生和政策制定者根据高危人群中的歧视和其他心理社会压力因素，有效地识别和预防产妇心理健康的差异。
