Gao Hui, Bi Ying, Wang Xin, Wang Miao, Zhou Mengxue, Lu Huiru, Gao Jimin, Chen Jun, Hu Yi
Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, University Town, Wenzhou, Zhejiang 325035, China.
Clinical Laboratory Department, Children's Hospital of Zhejiang University School of Medicine, No. 3333 Binsheng Road, Changhe Subdistrict, Binjiang District, Hangzhou, Zhejiang 310052, China.
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3628-3634. doi: 10.1021/acsbiomaterials.7b00405. Epub 2017 Nov 7.
Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. Doxorubicin (DOX) was encapsulated in CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution and antitumor effects of DOX-loaded nanoparticles were analyzed. DOX-loaded nanoparticles were accumulated in tumor cells upon near-infrared (NIR) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. In addition, NIR-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nanomedicines to tumors. These results suggest that NIR-guided thermal-responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors.
纳米药物在提高膀胱癌药物疗效和预防不良反应方面已显示出巨大潜力。在此，我们试图研究化学光热疗法对浅表性膀胱癌原位小鼠模型的影响。将阿霉素（DOX）包裹于CS/PNIPAAm@SWCNTs纳米颗粒中。分析了载有DOX的纳米颗粒的生物分布和抗肿瘤作用。在近红外（NIR）照射下，载有DOX的纳米颗粒在肿瘤细胞中蓄积，并在原位膀胱肿瘤小鼠中表现出强大的抗肿瘤活性。此外，NIR诱导的热疗增强了肿瘤血管的通透性，这可能是纳米药物对肿瘤特异性靶向的原因。这些结果表明，NIR引导的热响应纳米药物具有用于原位膀胱肿瘤化学光热疗法的潜力。
