Lechner H, Schmidt R, Bertha G, Justich E, Offenbacher H, Schneider G
Department of Neurology, University of Graz, Austria.
Stroke. 1988 Feb;19(2):263-5. doi: 10.1161/01.str.19.2.263.
The incidence, average number, and localization of lesions of the white matter detected by the T2-weighted nuclear magnetic resonance images among volunteers without cerebrovascular symptoms have been correlated with the number of risk factors for stroke. Accepted risk factors were arterial hypertension, diabetes mellitus, smoking, hypercholesterolemia, and cardiac disease. The 42 subjects examined were divided into Group A (0-1 risk factor, mean age 59.36 +/- 5.73 years), Group B (2 risk factors, mean age 61.54 +/- 8.33 years), and Group C (greater than or equal to 3 risk factors, mean age 62.57 +/- 9.83 years). Multiple risk factors among the age-matched groups was accompanied by a highly significant increase (p less than 0.001, Group A versus Group B; p less than 0.01, Group A versus Group C) of the incidence of white matter lesions. The average number of white matter lesions was increased (p less than 0.001) when Group A was compared with Groups B and C. Ninety-two percent of the white matter lesions were localized in watershed zones. Only 11 of the 155 abnormalities of the white matter detected by nuclear magnetic resonance imaging could be detected by computed tomography. White matter lesions in T2-weighted images appear to be an early stage of cerebrovascular disease.
在没有脑血管症状的志愿者中，通过T2加权核磁共振成像检测到的白质病变的发生率、平均数量及定位情况，已与中风的危险因素数量相关联。公认的危险因素包括动脉高血压、糖尿病、吸烟、高胆固醇血症和心脏病。接受检查的42名受试者被分为A组（0 - 1个危险因素，平均年龄59.36 ± 5.73岁）、B组（2个危险因素，平均年龄61.54 ± 8.33岁）和C组（≥3个危险因素，平均年龄62.57 ± 9.83岁）。在年龄匹配的组中，多种危险因素伴随着白质病变发生率的高度显著增加（A组与B组相比，p < 0.001；A组与C组相比，p < 0.01）。与B组和C组相比，A组的白质病变平均数量增加（p < 0.001）。92%的白质病变位于分水岭区。在核磁共振成像检测到的155处白质异常中，计算机断层扫描仅能检测出11处。T2加权图像中的白质病变似乎是脑血管疾病的早期阶段。
