Salat D H
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Charlestown, MA, USA; Neuroimaging Research for Veterans Center, Boston VA Healthcare System, Boston, MA, USA.
Neuroscience. 2014 Sep 12;276:174-86. doi: 10.1016/j.neuroscience.2013.11.041. Epub 2013 Dec 6.
Alterations in cerebrovascular structure and function may underlie the most common age-associated cognitive, psychiatric, and neurological conditions presented by older adults. Although much remains to understand, existing research suggests several age-associated detrimental conditions may be mediated through sometimes subtle small vessel-induced damage to the cerebral white matter. Here we review a selected portion of the vast work that demonstrates links between changes in vascular and neural health as a function of advancing age, and how even changes in low-to-moderate risk individuals, potentially beginning early in the adult age-span, may have an important impact on functional status in late life.
脑血管结构和功能的改变可能是老年人出现的最常见的与年龄相关的认知、精神和神经疾病的基础。尽管仍有许多有待了解之处，但现有研究表明，一些与年龄相关的有害状况可能是由小血管有时对脑白质造成的细微损伤介导的。在这里，我们回顾了大量研究中的一部分，这些研究表明随着年龄增长，血管健康和神经健康的变化之间存在联系，以及即使是低至中度风险个体的变化（可能在成年期早期就开始）如何可能对晚年的功能状态产生重要影响。
