对称和不对称BOIMPY荧光团的一锅法策略。
One-Pot Strategy for Symmetrical and Unsymmetrical BOIMPY Fluorophores.
作者信息
Freese Tyll, Patalag Lukas J, Merz J Luca, Jones Peter G, Werz Daniel B
机构信息
Technische Universität Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106 Braunschweig, Germany.
Technische Universität Braunschweig, Institute of Inorganic and Analytical Chemistry, Hagenring 30, 38106 Braunschweig, Germany.
出版信息
J Org Chem. 2021 Feb 5;86(3):3089-3095. doi: 10.1021/acs.joc.0c02860. Epub 2021 Jan 14.
We report the improved direct access to red-emitting BOIMPY fluorophores (λ ≈ 600 nm) via a simple one-pot approach. Our method starts from easily available benzimidazole-2-carboxylic acids and not only greatly improves the overall yields but also saves both costly reagents and time. In addition, the method facilitates the synthesis of novel unsymmetrical BOIMPY motifs. Therefore, these BOIMPY scaffolds derived from the BODIPY core become more accessible for applications as fluorophores at the appealing red edge of the visible spectrum.
我们报道了通过一种简单的一锅法改进直接获得发射红色荧光的BOIMPY荧光团（λ≈600 nm）的方法。我们的方法从易于获得的苯并咪唑-2-羧酸开始，不仅大大提高了总产率，还节省了昂贵的试剂和时间。此外，该方法有助于新型不对称BOIMPY基序的合成。因此，这些源自BODIPY核心的BOIMPY支架作为可见光谱中吸引人的红色边缘的荧光团，在应用中变得更容易获得。
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