Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell Biology Program, Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Urol Clin North Am. 2020 Nov;47(4S):e9-e16. doi: 10.1016/j.ucl.2020.10.004. Epub 2020 Dec 9.
Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.
复杂的免疫逃逸机制和缺乏预测免疫检查点阻断治疗反应的生物标志物，这两个因素共同影响了免疫疗法在前列腺癌患者中的治疗效果。作者回顾了前列腺癌中已确定和提名的免疫逃逸机制，并讨论了如何制定精确的治疗策略以提高免疫疗法的疗效。
