Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Dong Lake District, Nanchang, Jiangxi Province, 330000, China; Department of Intensive Care Unit, the Fifth People's Hospital of Shangrao City, No. 1 Jiannan Road, Xin Zhou District, Shangrao 334000, China.
Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Dong Lake District, Nanchang, Jiangxi Province, 330000, China.
Mol Immunol. 2021 Mar;131:191-200. doi: 10.1016/j.molimm.2020.12.038. Epub 2021 Jan 11.
Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in various pathophysiological processes of disease, such as cancer occurrence, viral invasion, and inflammatory damage. The main inflammatory body component, nod-like receptor protein 3 (NLRP3), is the trigger point of inflammatory reactions and inflammation-related diseases and coordinates the body's response to inflammation. At present, increasing evidence shows that the interaction of lncRNAs and the NLRP3 inflammasome plays an important role in the inflammatory response and different diseases. This may be involved in the development and progression of various diseases by activating signalling pathways and a variety of molecular regulatory mechanisms-this article reviews progress in research on the relationship between lncRNAs and the NLRP3 inflammasome under different conditions.
新兴证据表明，长链非编码 RNA（lncRNAs）参与疾病的各种病理生理过程，如癌症发生、病毒入侵和炎症损伤。主要的炎症体成分，核苷酸结合寡聚化结构域样受体蛋白 3（NLRP3），是炎症反应和炎症相关疾病的触发点，协调机体对炎症的反应。目前，越来越多的证据表明，lncRNAs 和 NLRP3 炎性体的相互作用在炎症反应和不同疾病中起着重要作用。这可能通过激活信号通路和多种分子调控机制，参与各种疾病的发生和发展——本文综述了不同条件下 lncRNAs 与 NLRP3 炎性体之间关系的研究进展。
