脓毒症：一种进化视角（从微生物角度看脓毒症与从重症监护医生角度看临床脓毒症）
Sepsis: An Evolutionary Perspective (Sepsis through the Eyes of a Microbe vs Clinical Sepsis through the Eyes of an Intensivist).
作者信息
Kapadia Farhad N
机构信息
Department of Medicine and Critical Care, Hinduja Hospital, Mumbai, Maharashtra, India.
出版信息
Indian J Crit Care Med. 2020 Dec;24(12):1165-1168. doi: 10.5005/jp-journals-10071-23670.
"Change of gene frequency in population" is the most fundamental concept of evolutionary biology. Human sepsis is a quantitative biological war between microbial genes and human genes, fought through their respective phenotypes. The prize of this war is an increase of gene frequency. Stating that sepsis is caused by a dysregulated host response is missing one half of the septic syndrome. Clinicians may gain a different perspective into the many intricacies of sepsis by conceptualizing it as an adaptive evolutionary process, rather than an abnormal physiological state. Clinicians may also get a deeper perspective by seeing it as a genotypic evolutionary process of natural selection rather than a phenotypic pathophysiological event. Kapadia FN. Sepsis: An Evolutionary Perspective (Sepsis through the Eyes of a Microbe vs Clinical Sepsis through the Eyes of an Intensivist). Indian J Crit Care Med 2020;24(12):1165-1168.
“群体中基因频率的改变”是进化生物学最基本的概念。人类败血症是微生物基因与人类基因之间通过各自表型进行的一场定量生物战。这场战争的奖赏是基因频率的增加。认为败血症是由宿主反应失调引起的，这忽略了败血症综合征的一半情况。临床医生通过将败血症概念化为一个适应性进化过程，而非一种异常生理状态，可能会对败血症的诸多复杂情况有不同的认识。临床医生若将其视为自然选择的基因型进化过程而非表型病理生理事件，或许也能有更深刻的认识。卡帕迪亚·FN。《败血症：一种进化视角（从微生物视角看败血症与从重症监护医生视角看临床败血症）》。《印度危重症医学杂志》2020年；24(12):1165 - 1168。
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