Wei Wenxing, Wu Yuangang, Zeng Yi, Shen Bin
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Jan 15;35(1):124-129. doi: 10.7507/1002-1892.202006068.
To summarize research progress of change in bone mineral density (BMD) after knee arthroplasty and its diagnostic methods, influencing factors, and drug prevention and treatment.
The relevant literature at home and abroad was reviewed and summarized from research status of the advantages and disadvantages of BMD assessment methods, the trend of changes in BMD after knee arthroplasty and its influencing factors, and the differences in effectiveness of drugs.
The central BMD and mean BMD around the prosthesis decrease after knee arthroplasty, which is closely associated with body position, age, weight, daily activities, and the fixation methods, design, and material of prosthesis. Denosumab, bisphosphonates, and teriparatide can decrease BMD loss after knee arthroplasty.
BMD after knee arthroplasty decreases, which is related to various factors, but the mechanism is unclear. At present, some inhibitors of bone resorption can decrease BMD loss after knee arthroplasty. However, its long-term efficacy remains to be further explored.
总结膝关节置换术后骨密度（BMD）变化及其诊断方法、影响因素和药物防治的研究进展。
从BMD评估方法优缺点的研究现状、膝关节置换术后BMD变化趋势及其影响因素、药物有效性差异等方面对国内外相关文献进行回顾和总结。
膝关节置换术后假体周围中心BMD和平均BMD降低，这与体位、年龄、体重、日常活动以及假体的固定方式、设计和材料密切相关。地诺单抗、双膦酸盐和特立帕肽可减少膝关节置换术后BMD丢失。
膝关节置换术后BMD降低，与多种因素有关，但其机制尚不清楚。目前，一些骨吸收抑制剂可减少膝关节置换术后BMD丢失。然而，其长期疗效仍有待进一步探索。
