Rabinowitz L
Department of Human Physiology, University of California, Davis 95616.
Am J Physiol. 1988 Feb;254(2 Pt 2):R381-8. doi: 10.1152/ajpregu.1988.254.2.R381.
Based on experimental observations on unanesthetized sheep, a hypothesis is proposed for the homeostatic control of potassium excretion in this ruminant. This hypothesis includes as a novel element a splanchnic sensor of potassium intake. Information provided by the splanchnic sensor contributes to the control of potassium excretion independently of the level of systemic plasma potassium or other conventional control factors. A mathematical model based on this hypothesis successfully simulates the relations between potassium excretion, plasma potassium, and oral and intravenous potassium input observed in sheep.
基于对未麻醉绵羊的实验观察，提出了一个关于这种反刍动物钾排泄稳态控制的假说。该假说包含一个新元素，即内脏钾摄入传感器。内脏传感器提供的信息独立于全身血浆钾水平或其他传统控制因素，有助于控制钾排泄。基于该假说的数学模型成功模拟了绵羊体内钾排泄、血浆钾以及口服和静脉输入钾之间的关系。
