Science, Mathematics & Technology Cluster, Singapore University of Technology and Design (SUTD), 8 Somapah Road, S487372, Singapore.
California Institute of Technology, Pasadena, CA, 91125, USA.
Bioessays. 2020 Sep;42(9):e2000046. doi: 10.1002/bies.202000046. Epub 2020 Jul 30.
Recent studies suggest that the tetracycline antibiotic minocycline, or its cousins, hold therapeutic potential for affective and psychotic disorders. This is proposed on the basis of a direct effect on microglia-mediated frontocortical synaptic pruning (FSP) during adolescence, perhaps in genetically susceptible individuals harboring risk alleles in the complement component cascade that is involved in this normal process of CNS circuit refinement. In reviewing this field, it is argued that minocycline is actually probing and modulating a deeply evolved and intricate system wherein psychosocial stimuli sculpt the circuitry of the "social brain" underlying adult behavior and personality. Furthermore, this system can generate psychiatric morbidity that is not dependent on genetic variation. This view has important ramifications for understanding "pathologies" of human social behavior and cognition as well as providing long-sought potential mechanistic links between social experience and susceptibility to mental and physical disease.
最近的研究表明，四环素类抗生素米诺环素或其类似物在情感和精神病障碍方面具有治疗潜力。这是基于其对青春期中小胶质细胞介导的额皮质突触修剪（FSP）的直接影响提出的，也许在遗传易感个体中，补体成分级联中的风险等位基因参与了中枢神经系统回路细化的这一正常过程。在回顾这一领域时，有人认为米诺环素实际上在探测和调节一个经过深度进化和复杂的系统，其中社会心理刺激塑造了“社会大脑”的电路，这是成年行为和个性的基础。此外，这个系统可以产生与遗传变异无关的精神疾病。这种观点对于理解人类社会行为和认知的“病理学”以及提供长期以来人们所寻求的社会经验与精神和身体疾病易感性之间的潜在机制联系具有重要意义。
