Painter R W, Clark W E, Deckers P J
Department of Surgery, Hartford Hospital, Connecticut 06115.
Am J Surg. 1988 Mar;155(3):387-90. doi: 10.1016/s0002-9610(88)80096-5.
A series of 245 fine-needle aspirations of solid breast masses has been reviewed. Seven aspirations were reported as unsatisfactory, 178 revealed benign masses, 7 were indeterminate, and 53 revealed malignancy. Fifty-two of 53 masses diagnosed on aspiration as malignant were confirmed by surgical biopsy (98 percent sensitivity). Open biopsy was carried out on 50 of 178 masses reported as negative on needle biopsy and benign masses were revealed in 46 cases (92 percent specificity). The remaining 128 masses with negative findings were observed and follow-up of 101 patients obtained. Cancer did not develop in any of these patients. Careful physical examination and mammography can predict if a breast mass is malignant or benign in 85 to 90 percent of patients. If fine-needle aspiration biopsy is added and performed by physicians and cytopathologists experienced in the technique, additional information is obtained which allows greater diagnostic accuracy and may eliminate many breast biopsies.
对245例乳腺实性肿块的细针穿刺抽吸样本进行了回顾性分析。7例抽吸样本报告为不满意，178例显示为良性肿块，7例结果不确定，53例显示为恶性。53例抽吸诊断为恶性的肿块中，52例经手术活检证实（敏感性98%）。对178例针吸活检报告为阴性的肿块中的50例进行了开放活检，46例显示为良性肿块（特异性92%）。其余128例结果为阴性的肿块进行了观察，并对101例患者进行了随访。这些患者均未发生癌症。仔细的体格检查和乳房X线摄影可在85%至90%的患者中预测乳腺肿块是恶性还是良性。如果加上由该技术经验丰富的医生和细胞病理学家进行的细针穿刺抽吸活检，可获得更多信息，提高诊断准确性，并可能避免许多乳腺活检。
