Institute of Biomedical Research, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, People's Republic of China.
Appl Microbiol Biotechnol. 2021 Feb;105(3):1007-1015. doi: 10.1007/s00253-021-11096-2. Epub 2021 Jan 15.
Transition metal ions are essential micronutrients for all living organisms and exert a wide range of effects on human health. The uptake of transition metal ions occurs primarily in the gastrointestinal tract, which is colonized by trillions of bacterial cells. In recent years, increasing studies have indicated that transition metals have regulatory effects on the gut microbiota. In view of the significant effect of the gut microbiota on human health and involvement in the pathogenesis of a wide range of diseases, in this paper, we provide a comprehensive discussion on the regulatory effects of four kinds of transition metal ions on the gut microbiota. A total of 20 animal model and human studies concerning the regulatory effects of four types of transition metal ions (i.e., iron, copper, zinc, and manganese) on gut microbiota were summarized. Both the deficiency and supplementation of these transition metal ions on the gut microbiota were considered. Furthermore, the potential mechanisms governing the regulatory effects of transition metal ions on the gut microbiota were also discussed. KEY POINTS : • Regulatory effects of iron, copper, zinc, and manganese on gut microbiota were reviewed. • Both deficiency and supplementation of metal ions on gut microbiota were considered. • Mechanisms governing effects of metal ions on gut microbiota were discussed.
过渡金属离子是所有生物必需的微量元素，对人类健康有广泛的影响。过渡金属离子的摄取主要发生在胃肠道中，这里定植着数以万亿计的细菌细胞。近年来，越来越多的研究表明，过渡金属对肠道微生物群具有调节作用。鉴于肠道微生物群对人类健康的重大影响及其参与多种疾病的发病机制，本文全面讨论了四种过渡金属离子（铁、铜、锌和锰）对肠道微生物群的调节作用。总结了 20 项关于四种类型过渡金属离子（铁、铜、锌和锰）对肠道微生物群调节作用的动物模型和人体研究。考虑了这些过渡金属离子对肠道微生物群的缺乏和补充。此外，还讨论了控制过渡金属离子对肠道微生物群调节作用的潜在机制。要点：
综述了铁、铜、锌和锰对肠道微生物群的调节作用。
考虑了金属离子对肠道微生物群缺乏和补充的影响。
讨论了金属离子对肠道微生物群作用的机制。
