Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston.
Robert Cizik Eye Clinic, Houston, TX.
J Glaucoma. 2021 May 1;30(5):436-443. doi: 10.1097/IJG.0000000000001793.
Lens extraction with endocycloplasty (LE/ECPL) results in greater angle deepening than LE alone in plateau iris eyes. This study directly compares an LE/ECPL treatment group with a control group.
Quantitatively determine the effect of LE/ECPL versus LE alone for eyes with plateau iris configuration/plateau iris syndrome (PIC/PIS) on angle parameters.
Patients with PIC/PIS who underwent LE/ECPL or LE alone were reviewed. Eyes with ultrasound biomicroscopy-documented PIC that underwent anterior segment optical coherence tomography examination before and after treatment were included. Angle parameters, angle opening distance (AOD), trabecular-iris space area (TISA), and trabecular-iris circumference volume (TICV) were calculated. Angle parameters were compared between treatments using a 2-sample t test. P-values were adjusted by the false discovery rate method (P*). A paired t test was used to compare treated (nasal) and untreated (temporal) angles in LE/ECPL-treated eyes.
Twenty-three eyes of 14 participants were included. Ten eyes (43%) eyes of 7 participants were treated with LE/ECPL, and 13 eyes (57%) of 7 participants were treated with LE alone. Angles were deepened in both groups (P<0.001). Changes in AOD, TISA, and TICV showed that the magnitude of deepening in treated (nasal) quadrants was greater in LE/ECPL eyes than in LE alone eyes (P<0.05). ECPL-treated angles deepened more than the untreated angles by AOD, TISA, and TICV (P<0.002).
Our study suggests that LE/ECPL is more effective than LE alone in opening the anterior chamber angle and that ECPL deepens treated angles more than untreated angles. This study directly compares an LE/ECPL treatment group with a control group, LE alone, allowing for separation of the effect of ECPL from LE.
与单纯晶状体切除术（LE）相比，晶状体囊内切除术（ECPL）联合 LE 可使房角加深更多，这在房角高褶虹膜眼中更为明显。本研究直接比较了 LE/ECPL 治疗组与对照组。
定量评估 LE/ECPL 联合 LE 与单纯 LE 治疗高褶虹膜形态/高褶虹膜综合征（PIC/PIS）患者的房角参数的效果。
回顾性分析接受 LE/ECPL 或单纯 LE 治疗的 PIC/PIS 患者。纳入经超声生物显微镜证实的房角高褶，并在治疗前后接受眼前节光学相干断层扫描检查的患者。计算房角参数、房角开放距离（AOD）、小梁虹膜空间面积（TISA）和小梁虹膜容积（TICV）。采用两样本 t 检验比较两种治疗方法的房角参数。采用错误发现率法（FDR）对 P 值进行调整（P*）。采用配对 t 检验比较 LE/ECPL 治疗眼的治疗（鼻侧）和未治疗（颞侧）眼的角度。
共纳入 14 名患者的 23 只眼。7 名患者的 10 只眼（43%）接受 LE/ECPL 治疗，7 名患者的 13 只眼（57%）接受单纯 LE 治疗。两组房角均加深（P<0.001）。AOD、TISA 和 TICV 的变化表明，LE/ECPL 治疗眼治疗（鼻侧）象限的加深幅度大于单纯 LE 治疗眼（P<0.05）。ECPL 治疗的角度比未治疗的角度通过 AOD、TISA 和 TICV 加深更多（P<0.002）。
本研究表明，与单纯 LE 相比，LE/ECPL 更能有效打开前房角，ECPL 加深治疗角度比未治疗角度更深。本研究直接比较了 LE/ECPL 治疗组与对照组，即单纯 LE，能够将 ECPL 的效果与 LE 分离。
