Smith B E, Siggins D
Department of Anaesthetics, Alexandra Hospital, Redditch, Worcestershire.
Anaesthesia. 1988 Jan;43(1):8-11. doi: 10.1111/j.1365-2044.1988.tb05413.x.
Sciatic nerve block was performed in two groups of patients using a low power peripheral nerve stimulator to aid nerve location. In group A 1% prilocaine with felypressin was used as the local anaesthetic agent in a volume of 0.25 ml/kg body weight. In group B 3% prilocaine with felypressin was used in a volume of 0.08 ml/kg body weight (i.e. equal total drug dosages). Use of the 3% solution resulted in highly significant reductions in the mean latency for analgesia of the nerve block and in the latency and degree of motor block achieved (p less than 0.005 in each case). The clinical value of high concentration, low volume nerve block is discussed.
在两组患者中使用低功率外周神经刺激器辅助神经定位进行坐骨神经阻滞。A组使用含去甲肾上腺素的1%丙胺卡因作为局部麻醉剂，剂量为0.25 ml/kg体重。B组使用含去甲肾上腺素的3%丙胺卡因，剂量为0.08 ml/kg体重（即总药物剂量相等）。使用3%溶液可使神经阻滞镇痛的平均潜伏期以及运动阻滞的潜伏期和程度显著降低（每种情况p均小于0.005）。讨论了高浓度、小容量神经阻滞的临床价值。
