Mechanobiology Institute, National University of Singapore, 117411, Singapore and Universal Biology Institute, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.
Phys Rev Lett. 2020 Dec 31;125(26):268104. doi: 10.1103/PhysRevLett.125.268104.
This Letter investigates what forms of cellular dynamic self-organization are caused through intercellular contact communication based on a theoretical model in which migrating cells perform contact following and contact inhibition and attraction of locomotion. Tuning those strengths causes varieties of dynamic patterns. This further includes a novel form of collective migration, snakelike dynamic assembly. Scrutinizing this pattern reveals that cells in this state can accurately respond to an external directional cue but have no spontaneous global polar order.
这封信件研究了基于理论模型的细胞间接触通讯所引起的细胞动态自组织形式,该模型中,迁移细胞进行接触后跟随、接触抑制和运动吸引。调整这些强度会导致各种动态模式。这进一步包括一种新的集体迁移形式,即蛇形动态组装。仔细研究这种模式表明,处于这种状态的细胞可以准确响应外部方向提示,但没有自发的全局极性秩序。