成人因 whipplei 属立克次体和念珠菌属感染引起的重症肺炎：2019 年病例系列研究。
Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series.
机构信息
Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Department of Radiology, The Second Hospital of Jilin University, Changchun, Jilin, China.
出版信息
BMC Pulm Med. 2021 Jan 15;21(1):29. doi: 10.1186/s12890-020-01384-4.
BACKGROUND
Whipple's disease is a chronic infectious disease caused by the Gram-positive bacterium Tropheryma whipplei (TW), which not only affects the gastrointestinal tract and causes malabsorption of nutrients, but several other systems, such as the cardiovascular system, central nervous system, the joints, and the vascular system, can also be simultaneously involved. The aim of this report was to be able to alert the clinician to severe pneumonia caused by TW combined with Candida sp.
CASE PRESENTATION
The case study was conducted on patients in September and November 2019. After routine examination and treatment, the results were not satisfactory. A bronchoalveolar lavage (BAL) using metagenomics next-generation sequencing was conducted on two adults who presented with fever, cough, and progressive dyspnea and who had no history of gastrointestinal symptoms, immunodeficiency diseases, or use of immunosuppressive agents. TW and Candida sp. were detected in in BAL.
CONCLUSIONS
This is a report of life-threatening pneumonia caused by TW combined with Candida sp. in a Chinese population.
背景
惠普尔病是由革兰阳性细菌泰勒马惠普尔菌（TW）引起的慢性传染病，不仅影响胃肠道，导致营养吸收不良，还可同时累及心血管系统、中枢神经系统、关节和血管系统等多个系统。本报告旨在提醒临床医生注意 TW 合并念珠菌引起的严重肺炎。
病例介绍
本病例研究于 2019 年 9 月和 11 月进行。对两名出现发热、咳嗽和进行性呼吸困难但无胃肠道症状、免疫缺陷疾病或使用免疫抑制剂史的成年人进行常规检查和治疗后，结果并不令人满意。在支气管肺泡灌洗液（BAL）中检测到 TW 和念珠菌。
结论
这是一例在中国人群中由 TW 合并念珠菌引起的危及生命的肺炎报告。
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