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暴露于强电场下的幼鼠和幼兔的发育情况。

Development of young rats and rabbits exposed to a strong electric field.

作者信息

Portet R, Cabanes J

机构信息

Laboratoire d'Adaptation Energétique à l'Environnement, Ecole Pratique des Hautes Etudes, Collège de France, Paris.

出版信息

Bioelectromagnetics. 1988;9(1):95-104. doi: 10.1002/bem.2250090109.

Abstract

Body growth and circulating levels of hormones were assessed in young rats and rabbits exposed to a 50-Hz electric field of 50 kV/m. Eight-week-old male rats were exposed 8 h/day for 4 weeks and rabbits were exposed 16 h/day from the last 2 weeks of gestation to 6 weeks after birth. The body and the organ growth of exposed rats were not statistically different from those of sham-exposed controls. No important differences from controls were observed in plasma levels of corticosterone, TSH, ACTH, and T4 or in adrenal levels of epinephrine, norepinephrine, and corticosterone although T3 was slightly, but significantly, decreased. No large histological changes in the thyroid or adrenals were noted. In rabbits, organ and body weights of exposed animals were comparable to those of controls. Plasma levels of various hormones (ACTH, GH, T3, T4, corticosterone, cortisol), serum glucose, triglycerides, and cholesterol were not significantly altered. Adrenal content of cortisol was lower, however, in exposed rabbits. No histological changes of the thyroid or adrenal glands were observed.

摘要

对暴露于50 kV/m的50 Hz电场中的幼鼠和幼兔的身体生长及激素循环水平进行了评估。8周龄雄性大鼠每天暴露8小时,持续4周,而兔子则从妊娠最后2周开始至出生后6周每天暴露16小时。暴露大鼠的身体和器官生长与假暴露对照组相比无统计学差异。在皮质酮、促甲状腺激素、促肾上腺皮质激素和甲状腺素的血浆水平以及肾上腺素、去甲肾上腺素和皮质酮的肾上腺水平方面,与对照组相比未观察到重要差异,尽管三碘甲状腺原氨酸略有但显著降低。甲状腺或肾上腺未发现明显的组织学变化。在兔子中,暴露动物的器官和体重与对照组相当。各种激素(促肾上腺皮质激素、生长激素、三碘甲状腺原氨酸、甲状腺素、皮质酮、皮质醇)的血浆水平、血糖、甘油三酯和胆固醇均未显著改变。然而,暴露兔子的肾上腺皮质醇含量较低。甲状腺或肾上腺未观察到组织学变化。

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