Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Sci Rep. 2021 Jan 15;11(1):1570. doi: 10.1038/s41598-021-81341-1.
It is generally believed that risk factors damage the coronary arteries, cause myocardial ischemia, and consequently change the shape of the heart. On the other hand, each of the risk factors may also have a negative effect on the heart. However, it is very difficult to examine the effects of each of these risk factors independently. Therefore, it is necessary to select an appropriate statistical method and apply it efficiently. In this study, the effects of coronary risk factors on left ventricular size and cardiac function were investigated using structure equation modeling (SEM), and were shown as Bayesian SEM-based frequency polygons using selected two-dimensional contours. This study showed that each risk factor directly affected the shape of the heart. Because vascular risk and heart failure risk are likely to evolve at the same time, managing risk factors is very important in reducing the heart failure pandemic.
人们普遍认为,危险因素会损害冠状动脉,导致心肌缺血,进而改变心脏的形状。另一方面,每种危险因素也可能对心脏产生负面影响。然而,要独立检查这些危险因素中的每一个的影响是非常困难的。因此,有必要选择一种合适的统计方法并有效地应用它。在这项研究中,使用结构方程建模(SEM)研究了冠状动脉危险因素对左心室大小和心脏功能的影响,并使用选定的二维轮廓以基于贝叶斯 SEM 的二维多边形显示。本研究表明,每个危险因素都直接影响心脏的形状。由于血管风险和心力衰竭风险很可能同时演变,因此管理危险因素对于减少心力衰竭的流行非常重要。