Department of Mathematics, University of Utah, 155 South 1400 East, Salt Lake City, UT, 84112, USA.
Bull Math Biol. 2021 Jan 16;83(3):17. doi: 10.1007/s11538-020-00849-1.
The Arabidopsis dormancy-germination transition is known to be environmentally cued and controlled by the competing hormones abscisic acid (ABA) and gibberellin (GA) produced by the seed. Recently, new molecular details have emerged concerning the propagation of red light through a complex gene regulatory network involving PhyB, PIF1, and RVE1. This network influences the formation of the PIF1-RVE1 complex [1,2]. The PIF1-RVE1 complex is a transcription factor that regulates the production of ABA and GA and helps shift the balance to high concentration of ABA and low concentration of GA, which corresponds to a dormant seed state. This newly discovered gene regulatory network has not been analyzed mathematically. Our analysis shows that this gene regulatory network exhibits switch-like bistability as a function of the red light input and makes a suite of biologically testable predictions concerning seed dormancy and germination in response to the amplitude and periodicity of an oscillatory red light input.
拟南芥的休眠-萌发转变已知是由环境线索和种子中产生的竞争激素脱落酸（ABA）和赤霉素（GA）控制的。最近，关于红光通过涉及 PhyB、PIF1 和 RVE1 的复杂基因调控网络传播的新分子细节已经出现。该网络影响 PIF1-RVE1 复合物的形成[1,2]。PIF1-RVE1 复合物是一种转录因子，可调节 ABA 和 GA 的产生，并有助于将平衡转移到高浓度 ABA 和低浓度 GA，这对应于休眠种子状态。这个新发现的基因调控网络尚未进行数学分析。我们的分析表明，这个基因调控网络作为红光输入的函数表现出开关式双稳性，并对种子休眠和萌发做出了一系列具有生物学可测试性的预测，这些预测涉及到对振荡红光输入的幅度和周期性的响应。
