Volgograd State Medical University, Ministry of Health of Russian Federation, Volgograd, Russia.
Volgograd Medical Research Center, Volgograd, Russia.
Bull Exp Biol Med. 2021 Jan;170(3):316-320. doi: 10.1007/s10517-021-05059-w. Epub 2021 Jan 16.
Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p<0.05) in comparison with zoniporide (35%; p<0.05).
在与对照组（注射溶剂）相比，慢性异丙肾上腺素中毒（皮下注射 L-异丙肾上腺素，每天 1 毫克/千克，持续 10 天）的大鼠心肌线粒体出现呼吸与 ATP 产生解偶联。NHE-1 抑制剂 zoniporide（腹膜内注射 1 毫克/千克，持续 13 天）和 BMA-1321 化合物（腹膜内注射 0.92 毫克/千克，持续 13 天）改善了异丙肾上腺素诱导的心力衰竭大鼠的线粒体功能：呼吸控制系数增加，对呼吸链复合物 II 的影响更大，复合物 II 是心力衰竭中 ROS 的主要来源。与 zoniporide（35%；p<0.05）相比，BMA-1321 的效果更为明显（53%；p<0.05）。
