NAP Adaptive Neuroethology, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, Tihany, Hungary.
Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):975-982. doi: 10.1093/gerona/glab014.
With the increase of life span, normal aging and age-related memory decline are affecting an increasing number of people; however, many aspects of these processes are still not fully understood. Although vertebrate models have provided considerable insights into the molecular and electrophysiological changes associated with brain aging, invertebrates, including the widely recognized molluscan model organism, the great pond snail (Lymnaea stagnalis), have proven to be extremely useful for studying mechanisms of aging at the level of identified individual neurons and well-defined circuits. Its numerically simpler nervous system, well-characterized life cycle, and relatively long life span make it an ideal organism to study age-related changes in the nervous system. Here, we provide an overview of age-related studies on L. stagnalis and showcase this species as a contemporary choice for modeling the molecular, cellular, circuit, and behavioral mechanisms of aging and age-related memory impairment.
随着寿命的延长，正常衰老和与年龄相关的记忆衰退正在影响越来越多的人；然而，这些过程的许多方面仍未被完全理解。尽管脊椎动物模型为理解与大脑衰老相关的分子和电生理变化提供了相当多的见解，但包括被广泛认可的软体动物模式生物——大型池塘蜗牛（Lymnaea stagnalis）在内的无脊椎动物，已被证明在研究个体神经元和明确界定的神经回路层面上的衰老机制方面非常有用。其相对简单的数字神经系统、特征明确的生命周期和较长的寿命使其成为研究神经系统与年龄相关变化的理想生物体。在这里，我们提供了关于 L. stagnalis 的与年龄相关研究的概述，并展示了这种物种作为模拟衰老和与年龄相关的记忆障碍的分子、细胞、回路和行为机制的现代选择。
