State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; School of Food Science, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; School of Food Science, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu, China.
Int J Biol Macromol. 2021 Mar 1;172:281-288. doi: 10.1016/j.ijbiomac.2021.01.044. Epub 2021 Jan 13.
The aim of the present study was to develop soy protein isolate (SPI) and κ-carrageenan (KC) composite hydrogels as a delivery system for hydrophilic compounds. The pigment of monascus yellow was used as a model. A systematic study was performed to characterize the rheological, textural, microstructural properties and in vitro digestion release profile of monascus yellow of the composite gels. The results of power law modeling, electrophoresis patterns and fourier transform infrared spectroscopy (FTIR) confirmed that non-covalent interactions were involved in the formation of SPI/KC composite hydrogels. Compared to pure κ-carrageenan hydrogels, the incorporation of SPI could promote the formation of tougher, more uniform and compact composite gels with sustained-release property. In addition, the release behaviors of monascus yellow entrapped in the hydrogel network can be well described by the Ritger-Peppas mathematical model. Overall, our study provided a promising strategy to enhance the sustained release performance of hydrogels in digestive conditions.
本研究旨在开发大豆分离蛋白(SPI)和κ-卡拉胶(KC)复合水凝胶作为亲水性化合物的递送系统。以红曲黄色素为模型进行了系统研究,以表征复合凝胶中红曲黄色素的流变学、质构、微观结构特性和体外消化释放特性。幂律模型、电泳图谱和傅里叶变换红外光谱(FTIR)的结果证实,非共价相互作用参与了 SPI/KC 复合水凝胶的形成。与纯 κ-卡拉胶水凝胶相比,SPI 的掺入可以促进更坚韧、更均匀和更致密的复合凝胶的形成,具有持续释放的特性。此外,包埋在水凝胶网络中的红曲黄色素的释放行为可以很好地用 Ritger-Peppas 数学模型来描述。总的来说,我们的研究为提高水凝胶在消化条件下的持续释放性能提供了一种有前途的策略。