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克服细胞穿透肽当前局限性的挑战。

Challenge to overcome current limitations of cell-penetrating peptides.

机构信息

Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.

Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.

出版信息

Biochim Biophys Acta Proteins Proteom. 2021 Apr;1869(4):140604. doi: 10.1016/j.bbapap.2021.140604. Epub 2021 Jan 14.

DOI:10.1016/j.bbapap.2021.140604
PMID:33453413
Abstract

The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.

摘要

生物膜的穿透性是药物输送的主要障碍。细胞穿透肽 (CPP) 是一种有效的载体，可以将各种有效载荷穿过生物膜输送。自发现以来，人们一直在对 CPP 进行严格研究，以揭示其潜在的穿透机制，并将 CPP 用于各种生物医学应用。本综述将重点介绍克服 CPP 在稳定性、选择性和功效方面的当前限制的各种策略。

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