Department of Dental Regenerative Biotechnology, Dental Research Institute and School of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.
Curr Pharm Biotechnol. 2011 Aug;12(8):1166-82. doi: 10.2174/138920111796117391.
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy. While different types of transporters currently exist, cell penetrating peptides (CPPs) have become one of the most popular and effective tools for intracellular drug delivery. Most of the original CPPs are short peptides with basic residues. The mechanism of CPP cell entry remains to be established; however, the CPPs can deliver any type of molecular cargo including solid nanoparticles. Herein, this paper will discuss the classification of CPPs, the mechanism of cell entry, the application of CPPs in tumor therapy, and recent advances in targeted cell penetration that involve CPPs.
抗癌药物的递送受到细胞膜通透性和肿瘤细胞缺乏选择性标志物的限制。细胞通透性与药物的生物利用度有关，因此被认为是实现治疗效果的关键步骤。虽然目前存在不同类型的转运体，但细胞穿透肽 (CPP) 已成为用于细胞内药物递送最受欢迎和最有效的工具之一。大多数原始 CPP 是带正电荷的短肽。CPP 进入细胞的机制尚未确定；然而，CPP 可以递送至任何类型的分子货物，包括固体纳米颗粒。本文将讨论 CPP 的分类、细胞进入的机制、CPP 在肿瘤治疗中的应用以及涉及 CPP 的靶向细胞穿透的最新进展。
