Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.
Spectrophon Ltd, Oppenheimer 7, Rehovot 7670107, Israel.
J Proteomics. 2021 Mar 20;235:104113. doi: 10.1016/j.jprot.2021.104113. Epub 2021 Jan 14.
We describe here a modern tool for exploring documents pertaining to the world Cultural Heritage while avoiding their contamination or damage. Known under the acronym EVA, it consists of a plastic foil of Ethylene Vinyl Acetate studded with strong cation and anion resins admixed with C and C hydrophobic beads. When applied to any surface such foils can harvest any type of surface material, which is then eluted and analyzed via standard means, such as GS/MS (typically for metabolites), MS/MS (for peptide and protein analysis), X-ray (for elemental analysis). We briefly review here a number of past data, such as screening of original documents by Bulgakov, Chekov, Casanova, Kepler, while dealing in extenso with very recent data, pertaining to Orwell and Stalin and analysis of the skin of an Egyptian mummy. The technique was also successfully applied to paintings, such as the Donna Nuda at the Hermitage in St. Petersburg, attributed to Leonardo and his school. This novel methodology represents a formidable tool for exploring the past life of famous authors, scientist and literates in that it can detect traces of their pathologies and even drug consumption left by saliva and sweat traces on their original hand-written documents.
我们在这里描述一种用于探索与世界文化遗产相关文献的现代工具，同时避免对其造成污染或损害。该工具缩写为 EVA，由乙烯-醋酸乙烯共聚物塑料箔制成，上面镶嵌着强阳离子和阴离子树脂，并混合有 C 和 C 疏水珠。当应用于任何表面时，这些箔片可以收集任何类型的表面材料，然后通过标准方法（例如 GS/MS（通常用于代谢物）、MS/MS（用于肽和蛋白质分析）、X 射线（用于元素分析）进行洗脱和分析。我们在这里简要回顾了一些过去的数据，例如 Bulgakov、Chekov、Casanova、Kepler 等对原始文献的筛选，同时还详细介绍了最近与 Orwell 和 Stalin 相关的数据，以及对埃及木乃伊皮肤的分析。该技术还成功应用于绘画作品，如圣彼得堡冬宫的《裸体女士》，该作品被认为是达芬奇及其学派的作品。这种新颖的方法为探索著名作家、科学家和文人的过去生活提供了一种强大的工具，因为它可以检测到他们的疾病痕迹，甚至可以检测到他们在原始手写文献上的唾液和汗水痕迹所留下的药物痕迹。
