Department of Neurosurgery, Bülent Ecevit University Medical Faculty, Zonguldak, Turkey
Department of Pathology, Bülent Ecevit University Medical Faculty, Zonguldak, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):1512-1520. doi: 10.3906/sag-2009-241.
BACKGROUND/AIM: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats.
A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the dura mater, and the wound was closed. A histopathological examination was undertaken to evaluate arachnoidal invasion and EF.
The results of EF in the Group 2 and Group 3 were significantly lower compared to the Group 1 (p = 0.023 and p = 0.002, respectively). No statistically significant difference was found between the Group 2 and Group 3 in terms of EF (p = 0.957). There was also no statistically significant difference between the mean arachnoidal invasion of the three groups (p > 0.171). However, the rate of arachnoidal invasion was the lowest in the Group 3.
Intraoperative Coseal, a polyethylene glycol polymer, tends to reduce the risk of epidural fibrosis, although this is not statistically significant.
背景/目的：研究可吸收性聚乙二醇水凝胶（RPGH，Coseal）在大鼠椎板切除术后对硬膜外纤维化（EF）的组织病理学影响。
共 24 只大鼠等分为三组。第一组在椎板切除术后不进行任何处理（对照组，第 1 组）。第二组在椎板切除术后止血，在硬膜外间隙放置 2mm 可吸收明胶海绵浸盐水，缝合伤口（第 2 组）。第三组在椎板切除术后止血，在硬脑膜上挤压 0.5mL RPGH（Coseal，第 3 组），缝合伤口。进行组织病理学检查以评估蛛网膜侵犯和 EF。
第 2 组和第 3 组的 EF 结果明显低于第 1 组（p=0.023 和 p=0.002）。第 2 组和第 3 组之间在 EF 方面无统计学差异（p=0.957）。三组之间的平均蛛网膜侵犯也无统计学差异（p>0.171）。然而，第 3 组的蛛网膜侵犯率最低。
术中使用聚乙二醇聚合物 Coseal 可降低硬膜外纤维化的风险，但这没有统计学意义。
