University of Melbourne, the Murdoch Children's Research Institute, Melbourne; and The Royal Children's Hospital, Melbourne, Australia.
J Am Acad Child Adolesc Psychiatry. 2021 Dec;60(12):1461-1463. doi: 10.1016/j.jaac.2021.01.003. Epub 2021 Jan 14.
There has been much discussion over the past few years about the potential benefits of supplementing traditional approaches to the assessment of mental health problems, which are based largely on reports of symptoms and observed behaviors, with more objective measures. Task-based neurocognitive measures are one of the more obvious approaches that can be considered. Potential tasks include those indexing executive functioning, through its key components: working memory, inhibitory control, set-shifting and planning, and those assessing more basic cognitive functions such as non-executive aspects of memory, processing speed, and response variability. Importantly, it is now becoming clear that the relationships between psychopathology and neurocognitive functioning are more complex than once thought. Neurocognitive deficits in executive and more basic cognitive functioning are seen across a broad range of psychiatric disorders, and although there may be subtle differences in cognitive profile across different disorders, most data support a more transdiagnostic approach. There is also considerable within-disorder heterogeneity, meaning that 2 individuals with the same disorder may have very different cognitive profiles. Also, although traditional, biologically based, causal models of mental disorders suggest a linear relationship between genetic and environmental causal factors leading to differences in brain structure and functioning that result in cognitive deficits with these manifested as psychiatric symptoms, recent data have questioned these linear relationships and suggested a greater degree of independence between neurocognitive deficits and psychopathology. Manfro et al. throws light on both aspects of this important issue, the potential for objective assessment and the relationship between neurocognition, psychopathology, and functional impairment.
在过去的几年里,人们一直在讨论补充传统方法评估心理健康问题的潜在益处,这些方法主要基于症状报告和观察到的行为,而采用更客观的措施。基于任务的神经认知测量是一种更明显的方法。潜在的任务包括评估执行功能的任务,通过其关键组成部分:工作记忆、抑制控制、转换和计划,以及评估更基本认知功能的任务,如记忆、处理速度和反应变异性的非执行方面。重要的是,现在越来越清楚的是,精神病理学和神经认知功能之间的关系比以前想象的要复杂得多。在广泛的精神障碍中都可以看到执行功能和更基本认知功能的神经认知缺陷,尽管不同障碍的认知特征可能存在细微差异,但大多数数据支持更跨诊断的方法。此外,还存在相当大的障碍内异质性,这意味着患有相同障碍的 2 个人可能具有非常不同的认知特征。此外,尽管传统的、基于生物学的精神障碍因果模型表明遗传和环境因果因素之间存在线性关系,导致大脑结构和功能的差异,从而导致认知缺陷,这些缺陷表现为精神症状,但最近的数据质疑了这些线性关系,并表明认知缺陷和精神病理学之间有更大的独立性。Manfro 等人探讨了这个重要问题的两个方面,即客观评估的潜力以及神经认知、精神病理学和功能障碍之间的关系。