全身性可卡因对大鼠脊髓伤害性反射活动的影响。
The effect of systemic cocaine on spinal nociceptive reflex activity in the rat.
作者信息
Pertovaara A, Belczynski C R, Morrow T J, Casey K L
机构信息
Department of Physiology, University of Michigan, Ann Arbor 48109.
出版信息
Brain Res. 1988 Jan 12;438(1-2):286-90. doi: 10.1016/0006-8993(88)91348-0.
In the anesthetized rat, cocaine (25 mg/kg i.p.), enhanced the frequency potentiation of nociceptively evoked polysynaptic discharges but did not affect the polysynaptic reflex discharge to single nociceptive stimuli or the habituation of this reflex to repetitive pinch stimuli. The non-nociceptive, short-latency reflex discharge was suppressed for 10-15 min after cocaine administration. The neurogenic extravasation response to antidromic cutaneous C-fiber stimulation was unaffected by cocaine. These findings suggest that systemic cocaine, in doses analgesic for the rat, does not suppress spinal nociceptive reflexes.
在麻醉大鼠中，可卡因（腹腔注射25毫克/千克）增强了伤害性诱发的多突触放电的频率增强，但不影响对单个伤害性刺激的多突触反射放电或该反射对重复捏压刺激的习惯化。给予可卡因后，非伤害性的短潜伏期反射放电被抑制10 - 15分钟。对逆向皮肤C纤维刺激的神经源性血管外渗反应不受可卡因影响。这些发现表明，对大鼠具有镇痛作用剂量的全身可卡因不会抑制脊髓伤害性反射。
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