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自闭症谱系障碍成人创伤后应激障碍风险增加:累积创伤和记忆缺陷的作用。

Heightened risk of posttraumatic stress disorder in adults with autism spectrum disorder: The role of cumulative trauma and memory deficits.

机构信息

University of Exeter, Washington Singer Building, Perry Road, Exeter, EX4 4QG, UK; King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience - PO80, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

University of Exeter, Washington Singer Building, Perry Road, Exeter, EX4 4QG, UK.

出版信息

Res Dev Disabil. 2021 Mar;110:103848. doi: 10.1016/j.ridd.2020.103848. Epub 2021 Jan 15.

Abstract

BACKGROUND

Individuals with Autism Spectrum Disorder (ASD) are known to be at increased risk of exposure to traumas such as maltreatment and abuse, however less is known about possible susceptibility towards the development of Posttraumatic Stress Disorder (PTSD) and associated risk factors.

AIMS

This study investigated the rates of trauma exposure and PTSD, and the role of cumulative trauma exposure and memory as risk factors for PTSD in adults who self-reported having received an ASD diagnosis, compared to a typically developing (TD) comparison group.

METHODS

Questionnaires assessing self-reported frequency of trauma exposure (LEC), PTSD symptomology (PCL-S) and memory (EMQ- R and BRIEF-A) were completed online by 38 ASD adults and 44 TD adults.

RESULTS

Rates of trauma exposure and PTSD symptomatology were significantly higher in the ASD group, compared to the TD group, with deficits in working memory and everyday memory mediating this association. Interestingly, a cumulative effect of trauma exposure on PTSD symptom severity was only found in the ASD group.

CONCLUSIONS

High rates of trauma and probable PTSD in ASD adults highlight the importance of routine screening. Cumulative trauma exposure and memory deficits may act to increase risk of PTSD in ASD; longitudinal research is called for.

摘要

背景

自闭症谱系障碍(ASD)患者已知面临更高的创伤暴露风险,例如虐待和滥用,但对于他们是否更容易患上创伤后应激障碍(PTSD)以及相关风险因素,了解较少。

目的

本研究调查了报告自己接受过 ASD 诊断的成年人与典型发育(TD)对照组相比,创伤暴露和 PTSD 的发生率,以及累积创伤暴露和记忆作为 PTSD 风险因素的作用。

方法

通过在线问卷评估了 38 名 ASD 成年人和 44 名 TD 成年人的创伤暴露频率(LEC)、PTSD 症状(PCL-S)和记忆(EMQ-R 和 BRIEF-A)。

结果

与 TD 组相比,ASD 组的创伤暴露和 PTSD 症状发生率明显更高,工作记忆和日常记忆缺陷介导了这种关联。有趣的是,仅在 ASD 组中发现了创伤暴露对 PTSD 症状严重程度的累积效应。

结论

ASD 成年人中创伤和可能的 PTSD 的高发生率强调了常规筛查的重要性。累积创伤暴露和记忆缺陷可能会增加 ASD 中 PTSD 的风险;需要进行纵向研究。

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