Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Biomed Pharmacother. 2021 Apr;136:111240. doi: 10.1016/j.biopha.2021.111240. Epub 2021 Jan 19.
The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various glycoproteins that collaborate and bind with each other to produce a bioactive polymer. Alterations in the composition and configuration of ECM elements influence the cellular phenotype, thus participating in the pathogenesis of several human disorders. Recent studies indicate the crucial roles of non-coding RNAs in the modulation of ECM. Several miRNAs such as miR-21, miR-26, miR-19, miR-140, miR-29, miR-30, miR-133 have been dysregulated in disorders that are associated with disruption or breakdown of the ECM. Moreover, expression of MALAT1, PVT1, SRA1, n379519, RMRP, PFL, TUG1, TM1P3, FAS-AS1, PART1, XIST, and expression of other lncRNAs is altered in disorders associated with the modification of ECM components. In the current review, we discuss the role of lncRNAs and miRNAs in the modification of ECM and their relevance with the pathophysiology of human disorders such as cardiac/ lung fibrosis, cardiomyopathy, heart failure, asthma, osteoarthritis, and cancers.
细胞外基质 (ECM) 构建了一个多方面的系统，用于各种结构蛋白、基质细胞分子、蛋白聚糖、透明质酸和各种糖蛋白的相互作用，这些物质相互协作并结合在一起，产生具有生物活性的聚合物。ECM 元素的组成和结构的改变会影响细胞表型，从而参与多种人类疾病的发病机制。最近的研究表明，非编码 RNA 在 ECM 的调节中起着关键作用。几种 miRNA，如 miR-21、miR-26、miR-19、miR-140、miR-29、miR-30、miR-133 在与 ECM 破坏或崩解相关的疾病中失调。此外，在与 ECM 成分修饰相关的疾病中，MALAT1、PVT1、SRA1、n379519、RMRP、PFL、TUG1、TM1P3、FAS-AS1、PART1、XIST 和其他 lncRNA 的表达也发生改变。在本综述中，我们讨论了 lncRNA 和 miRNA 在 ECM 修饰中的作用及其与人类疾病（如心脏/肺纤维化、心肌病、心力衰竭、哮喘、骨关节炎和癌症）的病理生理学的相关性。
