Zhang Lu, Zhou Jing, Kong Wei
Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Nat Rev Cardiol. 2025 May;22(5):333-353. doi: 10.1038/s41569-024-01103-0. Epub 2025 Jan 2.
The extracellular matrix is an essential component and constitutes a dynamic microenvironment of the vessel wall with an indispensable role in vascular homeostasis and disease. From early development through to ageing, the vascular extracellular matrix undergoes various biochemical and biomechanical alterations in response to diverse environmental cues and exerts precise regulatory control over vessel remodelling. Advances in novel technologies that enable the comprehensive evaluation of extracellular matrix components and cell-matrix interactions have led to the emergence of therapeutic strategies that specifically target this fine-tuned network. In this Review, we explore various aspects of extracellular matrix biology in vascular development, disorders and ageing, emphasizing the effect of the extracellular matrix on disease initiation and progression. Additionally, we provide an overview of the potential therapeutic implications of targeting the extracellular matrix microenvironment in vascular diseases.
细胞外基质是血管壁的重要组成部分，构成了一个动态的微环境，在血管稳态和疾病中发挥着不可或缺的作用。从早期发育到衰老，血管细胞外基质会根据不同的环境信号发生各种生化和生物力学改变，并对血管重塑发挥精确的调控作用。能够全面评估细胞外基质成分和细胞-基质相互作用的新技术取得进展，促使了专门针对这一精细调控网络的治疗策略的出现。在本综述中，我们探讨了细胞外基质生物学在血管发育、疾病和衰老中的各个方面，强调了细胞外基质对疾病起始和进展的影响。此外，我们还概述了针对血管疾病中细胞外基质微环境的潜在治疗意义。
