KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.
Wiad Lek. 2020;73(11):2438-2442.
The aim: Was to improve the effectiveness of the treatment of cognitive impairment in patients with hypertension and type 2 diabetes.
Materials and methods: 56 patients (11 women and 45 men, average age 61.7 ± 4.3 years) with hypertension II, 2 degree and type 2 diabetes (average severity, subcompensation stage) were examined. 40 patients had moderate CI and 16 had mild CI. After the examination, the patients were divided into two groups and treated accordingly. The control group consisted of 20 healthy individuals.
Results: Vascular brain lesions that cause hypertension and diabetes very often lead to impaired cognitive function whose therapeutic correction has received little attention, especially in the pre-operative stages. 56 patients have been examined to study the efficacy and safety a combination of Phenibut and Ipidacrine as an additional therapy to standard basic treatment (antihypertensive and hypoglycemic) for the correction of cognitive dysfunction in patients with comorbidity of hypertension and type 2 diabetes mellitus.
Conclusions: One month after the beginning of the treatment, an improvement in psycho-emotional state and psychometric parameters was identified, which was manifested by an increase in concentration of attention, memory, psychomotor functions, speech activity together with normalization of blood pressure and metabolic parameters.
提高高血压合并 2 型糖尿病患者认知功能障碍治疗效果。
检查了 56 例（11 名女性和 45 名男性，平均年龄 61.7±4.3 岁）高血压 II 级、2 度和 2 型糖尿病（平均严重程度，代偿期）患者。40 例患者有中度 CI，16 例有轻度 CI。检查后，患者被分为两组并进行相应治疗。对照组包括 20 名健康个体。
引起高血压和糖尿病的血管性脑损伤非常常见，导致认知功能障碍，其治疗纠正尚未得到太多关注，尤其是在术前阶段。检查了 56 例患者，以研究 Phenibut 和 Ipidacrine 联合治疗作为标准基础治疗（抗高血压和降血糖）的附加治疗，用于纠正高血压和 2 型糖尿病合并症患者的认知功能障碍。
治疗开始后 1 个月，观察到心理-情绪状态和心理计量学参数的改善，表现为注意力、记忆力、运动功能、言语活动的集中注意力增加，同时血压和代谢参数正常化。
