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老年爱尔兰成年人入住急性内科医院时发生谵妄的情况:一项前瞻性队列研究。

Delirium occurrence in older Irish adults admitted to an acute medical hospital: a prospective cohort study.

机构信息

Sligo Leitrim Mental Health Services, Ballytivnan, Sligo, Ireland.

Sligo Medical Academy, NUI Galway, The Mall, Rathquarter, Sligo, Ireland.

出版信息

Ir J Psychol Med. 2023 Sep;40(3):369-377. doi: 10.1017/ipm.2020.133. Epub 2021 Jan 18.

Abstract

OBJECTIVES

Delirium, which is associated with adverse health outcomes, is poorly detected in hospital settings. This study aimed to determine delirium occurrence among older medical inpatients and to capture associated risk factors.

METHODS

This prospective cohort study was performed at an Irish University Hospital. Medical inpatients 70 years and over were included. Baseline assessments within 72 hours of admission included delirium status and severity as determined by the Revised Delirium Rating Scale (DRS-R-98), cognition, physical illness severity and physical functioning. Pre-existing cognitive impairment was determined with Short Informant Questionnaire on Cognitive Decline (IQCODE). Serial assessment of delirium status, cognition and the physical illness severity were undertaken every 3 (±1) days during participants' hospital admission.

RESULTS

Of 198 study participants, 92 (46.5%) were women and mean age was 80.6 years (s.d. 6.81; range 70-97). Using DRS-R-98, 17.7% ( = 35) had delirium on admission and 11.6% ( = 23) had new-onset delirium during admission. In regression analysis, older age, impaired cognition and lower functional ability at admission were associated with a significant likelihood of delirium.

CONCLUSIONS

In this study, almost one-third of older medical inpatients in an acute hospital had delirium during admission. Findings that increasing age, impaired cognition and lower functional ability at admission were associated with increased delirium risk suggest target groups for enhanced delirium detection and prevention strategies. This may improve clinical outcomes.

摘要

目的

谵妄与不良健康结局相关,但在医院环境中往往难以被发现。本研究旨在确定老年住院患者中谵妄的发生情况,并捕捉相关的风险因素。

方法

这是一项在爱尔兰大学医院进行的前瞻性队列研究。纳入 70 岁及以上的住院内科患者。入院后 72 小时内进行基线评估,包括使用修订后的谵妄评定量表(DRS-R-98)确定的谵妄状态和严重程度、认知功能、躯体疾病严重程度和身体功能。使用简短认知下降询问表(IQCODE)确定是否存在预先存在的认知障碍。在患者住院期间,每 3(±1)天进行一次谵妄状态、认知和躯体疾病严重程度的连续评估。

结果

在 198 名研究参与者中,92 名(46.5%)为女性,平均年龄为 80.6 岁(标准差 6.81;范围 70-97)。使用 DRS-R-98,入院时 17.7%(=35)有谵妄,住院期间新发谵妄 11.6%(=23)。回归分析显示,入院时年龄较大、认知功能受损和功能能力较低与发生谵妄的可能性显著相关。

结论

在这项研究中,近三分之一的急性医院老年内科住院患者在住院期间出现谵妄。研究结果表明,年龄增长、入院时认知功能受损和功能能力降低与谵妄风险增加相关,提示需要针对这些群体加强谵妄的检测和预防策略。这可能会改善临床结局。

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