Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
J Dev Orig Health Dis. 2021 Dec;12(6):829-848. doi: 10.1017/S2040174420001245. Epub 2021 Jan 18.
While birth cohorts are shaped by underpinning life course frameworks, few if any report how they select them. This review aimed to (1) summarise publicly available frameworks relevant to planning and communicating large new early-life cohorts and (2) help select frameworks to guide and communicate Generation Victoria (GenV), a whole-of-state birth and parent cohort in planning in the state of Victoria, Australia. We identified potential frameworks from prior knowledge, networks and a pragmatic literature search in 2019. We considered for inclusion only frameworks with an existing visual graphic. We summarised each framework's concept, then judged it on a seven-item matrix (Scope, Dimensions, Outcomes, Life course, Mechanisms, Multi-age, and Visual Clarity) to be of high, intermediate or low relevance to GenV. We presented and evaluated 14 life course frameworks across research and policy. Two, nine and three frameworks, respectively, were ranked as high, intermediate and low relevance to GenV, although none totally communicated its scope and intent. Shonkoff's biodevelopmental framework was selected as GenV's primary framework, adapted to include ongoing feedback loops through the life course and influence of an individual's outcomes on the next generation. Because conceptual simplicity precluded the primary framework from capturing the wide range of relevant exposures, we selected the Australian Institute of Health and Welfare's person-centred model as a secondary framework. This summary of existing life course frameworks may prove helpful to other cohorts in planning. Our transparent process and focus on visual communication are already assisting in explaining and selecting measures for GenV. The feasibility, comprehension and validity of these frameworks could be further tested at implementation.
虽然出生队列是由潜在的生命历程框架塑造的，但很少有研究报告说明它们是如何选择这些队列的。本研究旨在：(1) 总结与规划和沟通大型新的早期生命队列相关的公开可用框架；(2) 帮助选择框架，指导和沟通澳大利亚维多利亚州（维多利亚州）的整个州出生和父母队列——维多利亚一代（GenV）。我们从先前的知识、网络和务实的文献搜索中确定了潜在的框架。我们只考虑纳入具有现有可视化图形的框架。我们总结了每个框架的概念，然后根据一个包含七个项目的矩阵（范围、维度、结果、生命历程、机制、多年龄和可视化清晰度）对其进行判断，以确定其与 GenV 的相关性高低。我们展示并评估了横跨研究和政策的 14 个生命历程框架。其中，分别有两个、九个和三个框架被认为与 GenV 高度、中度和低度相关，尽管没有一个框架完全传达了其范围和意图。Shonkoff 的生物发育框架被选为 GenV 的主要框架，适用于通过生命历程包括持续的反馈回路和个体结果对下一代的影响。由于主要框架无法捕捉到广泛的相关暴露，因此我们选择了澳大利亚健康与福利研究所的以人为中心的模型作为次要框架。这些现有生命历程框架的总结可能对其他队列的规划有所帮助。我们透明的过程和对可视化沟通的关注，已经在帮助解释和选择 GenV 的措施方面提供了帮助。这些框架的可行性、理解性和有效性可以在实施过程中进一步测试。
