Department of Pathology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
Department of Radiology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
Rev Esp Patol. 2021 Jan-Mar;54(1):65-69. doi: 10.1016/j.patol.2020.06.001. Epub 2020 Jul 21.
Inflammatory fibroid polyps (IFPs) are rare mesenchymal neoplasms affecting the gastrointestinal tract which are considered benign and noninvasive. We present a case of an invasive IFP in a 46-year-old woman who presented with signs of intestinal obstruction due to ileal intussusception. A segment of the small intestine was resected and subsequently intestinal continuity was restored. A polypoid lesion was found obstructing the lumen. Histopathology revealed a mesenchymal proliferation of spindle and stellate cells, without cytological atypia, arranged in a fibromyxoid stroma. The tumor cells were located in the submucosa but also infiltrated the muscularis propria and the subserosa and were CD34 positive. The molecular study by PCR showed mutation in exon 12 of the PDGFRA gene. IFP is considered a true neoplasm and can also be considered as a potentially invasive lesion.
炎性纤维息肉（IFP）是一种罕见的影响胃肠道的间叶性肿瘤，被认为是良性且非侵袭性的。我们报告了一例 46 岁女性侵袭性 IFP 病例，该患者因回肠套叠出现肠梗阻的迹象。切除了一小段小肠，随后恢复了肠道连续性。发现一个息肉样病变阻塞了管腔。组织病理学显示梭形和星状细胞的间叶性增殖，无细胞学异型性，排列在纤维黏液样基质中。肿瘤细胞位于黏膜下层，但也浸润固有肌层和浆膜下层，并且 CD34 阳性。PCR 分子研究显示 PDGFRA 基因外显子 12 突变。IFP 被认为是一种真正的肿瘤，也可以被认为是一种潜在的侵袭性病变。
