Department of Nephrology, Hospital Carlos Van Buren, Valparaiso. Street San Ignacio 725, Valparaíso, Chile.
Department of Nephrology, Hospital 12 de Octubre, Avda. de Córdoba, s/n Madrid, PC: 28041, Spain.
Transfus Apher Sci. 2021 Apr;60(2):103046. doi: 10.1016/j.transci.2020.103046. Epub 2021 Jan 2.
The recurrence of primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) appears in 30 % of the recipients. Sometimes it can cause the loss of the allograft. Although many treatments for this condition have been reported, 20 %-40 % of the affected patients are refractory or presents frequents relapses. In this paper we describe the evolution of three recipients treated with long-term plasmapheresis therapy after a recurrence of FSGS with a bad or incomplete response to other treatments. Although our findings require confirmation, long-term plasmapheresis could be a therapeutic option for this condition.
原发性局灶节段性肾小球硬化症（FSGS）在肾移植（KT）后复发的发生率为 30%。它有时会导致移植物丢失。尽管已经报道了许多针对这种疾病的治疗方法，但仍有 20%-40%的受影响患者对治疗有抗性或经常复发。在本文中，我们描述了三名患者在对其他治疗方法反应不佳或不完全的 FSGS 复发后接受长期血浆置换治疗的情况。尽管我们的发现需要进一步证实，但长期血浆置换可能是治疗这种疾病的一种选择。
