Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Theranostics. 2021 Jan 1;11(6):2755-2769. doi: 10.7150/thno.56174. eCollection 2021.
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs), a class of endogenous ncRNAs with unique covalently closed loops, have attracted great attention in regard to various diseases, especially cancers. Compelling studies have suggested that circRNAs are aberrantly expressed in different cancer tissues and cell types, including PC. More specifically, circRNAs can modify the proliferation, progression, tumorigenesis and chemosensitivity of PC, and some circRNAs could serve as biomarkers for diagnosis and prognosis. Herein, we summarize what is currently known to be related to the biogenesis, functions and potential roles of human circRNAs in PC and their application prospects for PC clinical treatments.
胰腺癌（PC）是全球癌症相关死亡的重要原因之一，是预后最差的恶性肿瘤之一。环状 RNA（circRNA）是一类具有独特共价闭合环的内源性非编码 RNA，在各种疾病中，特别是癌症中引起了广泛关注。有说服力的研究表明，circRNA 在不同的癌症组织和细胞类型中表达异常，包括 PC。更具体地说，circRNA 可以修饰 PC 的增殖、进展、肿瘤发生和化疗敏感性，一些 circRNA 可以作为诊断和预后的生物标志物。本文总结了目前已知的与人类 circRNA 在 PC 中的生物发生、功能和潜在作用及其在 PC 临床治疗中的应用前景有关的内容。
