Shaw Jawaid, Tate Victoria, Hanson Jennifer, Bajaj Jasmohan S
Division of Hospital Medicine, Virginia Commonwealth University, Richmond, Virginia.
Department of Nutrition, McGuire VA Medical Center, Richmond, Virginia.
Curr Hepatol Rep. 2020 Mar;19(1):13-22. doi: 10.1007/s11901-020-00510-4. Epub 2020 Mar 5.
The burden of malnutrition is high in patients with cirrhosis, especially in those with hepatic encephalopathy (HE). This has a bearing on increased morbidity and mortality. Heightened attention needs to be paid to screen the patients at high nutritional risk both in the outpatient and hospitalized settings. This review summarizes the current evidence for nutritional support in HE patients and compares the recommendations about nutritional requirement as laid out by various organizations.
On survey of the literature, there is a consensus on avoiding protein restriction of the diets in HE patients along with uniform recommendations on caloric requirements. An exciting field of manipulating the gut microbiome in nutritional sciences may hold promise as well as there may be a future role for branched chain amino acids in nutritional management of HE patients.
Even though the data suggest that nutritional improvement lead to better outcomes including lower readmission rates in cirrhosis, operationalizing these into practice remains a challenge. To achieve this, a multi-disciplinary approach with nutritional education of the frontline care providers, earlier nutritional risk screening of patients, involvement of the nutrition professionals as part of the team and repeated dietary counseling for the patient and caregiver/s is required. Ultimately, this may need more focus, resource allocation and uniform guidelines across all countries to make this a success.
肝硬化患者营养不良负担较重,尤其是肝性脑病(HE)患者。这与发病率和死亡率增加相关。在门诊和住院环境中,都需要更加关注筛查高营养风险患者。本综述总结了目前关于HE患者营养支持的证据,并比较了各组织提出的营养需求建议。
通过对文献的调查,对于避免HE患者饮食中蛋白质限制以及关于热量需求的统一建议已达成共识。营养科学中操纵肠道微生物群这一令人兴奋的领域可能也有前景,并且支链氨基酸在HE患者营养管理中可能会有未来作用。
尽管数据表明营养改善可带来更好的结果,包括降低肝硬化患者的再入院率,但将这些付诸实践仍然是一项挑战。要实现这一点,需要采取多学科方法,对一线护理人员进行营养教育,对患者进行早期营养风险筛查,营养专业人员作为团队的一部分参与其中,并对患者及其照顾者进行反复的饮食咨询。最终,这可能需要所有国家更加关注、资源分配以及统一的指导方针才能取得成功。